The Chaperonopathies

preview-18
  • The Chaperonopathies Book Detail

  • Author : Alberto J.L. Macario
  • Release Date : 2013-04-10
  • Publisher : Springer Science & Business Media
  • Genre : Medical
  • Pages : 126
  • ISBN 13 : 9400746679
  • File Size : 14,14 MB

The Chaperonopathies by Alberto J.L. Macario PDF Summary

Book Description: This Brief provides a concise review of chaperonopathies, i.e., diseases in which molecular chaperones play an etiologic-pathogenic role. Introductory chapters deal with the chaperoning system and chaperoning teams and networks, HSP-chaperone subpopulations, the locations and functions of chaperones, and chaperone genes in humans. Other chapters present the chaperonopathies in general, including their molecular features and mechanistic classification into by defect, excess, or mistake. Subsequent chapters discuss the chaperonopathies in more detail, focusing on their distinctive characteristics: primary or secondary; quantitative and/or qualitative; structural and hereditary or acquired; genetic polymorphisms; gene dysregulation; age-related; associated with cancer, chronic inflammatory conditions, and autoimmune diseases. The interconnections between the chaperoning and the immune systems in cancer development, chronic inflammation, autoimmunity, and ageing are outlined, which leads to a discussion on the future prospects of chaperonotherapy. The latter may consist of chaperone gene and protein replacement/supplementation in cases of deficiency and of gene or protein blocking when the chaperone actively promotes disease. The last chapter presents the extracellular chaperones and details on how the chaperone Hsp60 is secreted into the extracellular space and, thus, appears in the blood of cancer patients with potential to participate in carcinogenesis and chronic inflammation and autoimmunity. Chaperones as clinically useful biomarkers are mentioned when pertinent. Likewise, guidelines for clinical evaluation of chaperonopathies and for their histopathological and molecular identification are provided throughout. The book also provides extensive bibliography organized by chapter and topic with comments.

Disclaimer: www.yourbookbest.com does not own The Chaperonopathies books pdf, neither created or scanned. We just provide the link that is already available on the internet, public domain and in Google Drive. If any way it violates the law or has any issues, then kindly mail us via contact us page to request the removal of the link.

The Chaperonopathies

The Chaperonopathies

File Size : 73,73 MB
Total View : 8864 Views
DOWNLOAD

This Brief provides a concise review of chaperonopathies, i.e., diseases in which molecular chaperones play an etiologic-pathogenic role. Introductory chapters

Monoclonal Antibodies against Bacteria

Monoclonal Antibodies against Bacteria

File Size : 32,32 MB
Total View : 4336 Views
DOWNLOAD

Monoclonal Antibodies against Bacteria, Volume I explores the generation, characterization, and utilization of monoclonal antibodies against bacteria and on oth

Monoclonal Antibodies Against Bacteria

Monoclonal Antibodies Against Bacteria

File Size : 1,1 MB
Total View : 2260 Views
DOWNLOAD

Monoclonal Antibodies Against Bacteria, Volume II provides the basis for understanding new developments of practical importance in the health sciences within th

Heat Shock Proteins in Neuroscience

Heat Shock Proteins in Neuroscience

File Size : 9,9 MB
Total View : 6485 Views
DOWNLOAD

The book Heat Shock Proteins in Neuroscience provides the most comprehensive review on contemporary knowledge on the role of HSP in signaling pathways relevant

Cell Separation

Cell Separation

File Size : 4,4 MB
Total View : 8883 Views
DOWNLOAD

Cell Separation: Methods and Selected Applications, Volume 2 provides information pertinent to the design and application of methods for the separation of cells