The Changing Faces of Glutathione, a Cellular Protagonist

Released on by Alfonso Pompella
preview-18

  • The Changing Faces of Glutathione, a Cellular Protagonist Book Detail

  • Author : Alfonso Pompella
  • Release Date : 2015-07-17
  • Publisher : Frontiers Media SA
  • Genre : Pharmacology
  • Pages : 144
  • ISBN 13 : 2889195953
  • File Size : 73,73 MB
DOWNLOAD BOOK

The Changing Faces of Glutathione, a Cellular Protagonist by Alfonso Pompella PDF Summary

Book Description: Glutathione (GSH) has been described for a long time just as a defensive reagent against the action of toxic xenobiotics (drugs, pollutants, carcinogens), both directly and as a cofactor for GSH transferases. As a prototype antioxidant, it has been involved in cell protection from the noxious effect of excess oxidant stress, both directly and as a cofactor of glutathione peroxidases. In addition, it has long been known that GSH is capable of forming disulfide bonds with cysteine residues of proteins, and the relevance of this mechanism ("S-glutathionylation") in regulation of protein function has been well documented in a number of research fields. Rather paradoxically, it has also been highlighted that GSH—and notably its catabolites, as originated by metabolism by gamma-glutamyltransferase—can promote oxidative processes, by participating in metal ion-mediated reactions eventually leading to formation of reactive oxygen species and free radicals. Also, a fundamental role of GSH has been recognized in the storage and transport of nitric oxide (NO), in the form of S-nitrosoglutathione (GSNO). The significance of GSH as a major factor in regulation of cell life, proliferation, and death, can be regarded as the integrated result of all these roles, as well as of more which are emerging in diverse fields of biology and pathophysiology. Against this background, modulation of GSH levels and GSH-related enzyme activities represents a fertile field for experimental pharmacology in numerous and diverse perspectives of animal, plant and microbiologic research. This research topic includes 14 articles, i.e. 4 Opinion Articles, 6 Reviews, and 4 Original Research Articles. The contributions by several distinguished research groups, each from his own standpoint of competence and expertise, provide a comprehensive and updated view over the diverse roles, the changing faces of GSH and GSH-related enzymes in cell’s health, disease and death.

Disclaimer: www.yourbookbest.com does not own The Changing Faces of Glutathione, a Cellular Protagonist books pdf, neither created or scanned. We just provide the link that is already available on the internet, public domain and in Google Drive. If any way it violates the law or has any issues, then kindly mail us via contact us page to request the removal of the link.

Free Radicals in Biology and Medicine

Free Radicals in Biology and Medicine

File Size : 55,55 MB
Total View : 3308 Views
DOWNLOAD

Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research. Now in its fifth edition, the book has be