Animal-friendly methods for rodent behavioral testing in neuroscience research

Released on by Raffaele d’Isa
preview-18

  • Animal-friendly methods for rodent behavioral testing in neuroscience research Book Detail

  • Author : Raffaele d’Isa
  • Release Date : 2024-07-03
  • Publisher : Frontiers Media SA
  • Genre : Science
  • Pages : 229
  • ISBN 13 : 2832551157
  • File Size : 70,70 MB
DOWNLOAD BOOK

Animal-friendly methods for rodent behavioral testing in neuroscience research by Raffaele d’Isa PDF Summary

Book Description: Rodent behavioral testing has been used to study brain functions since the 1890s and has become a gold-standard model in modern neuroscience. Up to the 1950s, most behavioral tests on laboratory rodent models were based on punishments and rewards. Both approaches can lead to a certain degree of animal pain or suffering. Punishments involved the employment of painful stimuli, typically electric shocks. Passive avoidance and fear conditioning tests, among the most widely used behavioral paradigms used to evaluate learning and memory in rodents, can be performed using only a single brief shock. Other tests, such as the active avoidance, might require up to tens or hundreds of shocks, strongly challenging the psychological welfare of the model animals. On the other hand, tests based on rewards, which apparently may seem more ethical, actually still induce suffering in the animals, as food rewards are almost always associated with a food restriction protocol, in order to motivate food-seeking behavior. Rodents are starved for days before starting the test and kept under food restriction for the whole duration of the test. The distress during the testing session is only a minimal part compared to the stress lived outside of the testing session, which is prolonged and continuous. Analogously, liquid rewards commonly rely on a previous water restriction protocol to use thirst as motivation. Animal stress is not only an ethical issue per se, but also an important factor potentially impacting on the reliability and reproducibility of experimental results.

Disclaimer: www.yourbookbest.com does not own Animal-friendly methods for rodent behavioral testing in neuroscience research books pdf, neither created or scanned. We just provide the link that is already available on the internet, public domain and in Google Drive. If any way it violates the law or has any issues, then kindly mail us via contact us page to request the removal of the link.

Mouse Behavioral Testing

Mouse Behavioral Testing

File Size : 31,31 MB
Total View : 7734 Views
DOWNLOAD

Mouse Behavioral Testing: How to Use Mice in Behavioral Neuroscience provides detailed explanations of how to conduct an experiment on mouse behavior from the i

A Researcher's Guide to Rodent Behavior

A Researcher's Guide to Rodent Behavior

File Size : 32,32 MB
Total View : 2487 Views
DOWNLOAD

A Researcher's Guide to Rodent Behavior: Experimental Designs, Methods and Protocols, Volume 32 provides a comprehensive guide to all forms of behavioral proces