Automated Synthesis of the Lewis Blood Group Oligosaccharides

Released on by Kerry Routenberg Love
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  • Automated Synthesis of the Lewis Blood Group Oligosaccharides Book Detail

  • Author : Kerry Routenberg Love
  • Release Date : 2004
  • Publisher :
  • Genre :
  • Pages : 323
  • ISBN 13 :
  • File Size : 87,87 MB
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Automated Synthesis of the Lewis Blood Group Oligosaccharides by Kerry Routenberg Love PDF Summary

Book Description: Cell-surface carbohydrates are markers of specific cell types. These oligosaccharides are involved in recognition, adhesion, and signal transduction events. Advances in molecular glycobiology rely heavily on straightforward access to structurally defined oligosaccharides, but traditional syntheses of complex carbohydrates have been very laborious. Development of a novel linker and monitoring of each glycosylation reaction during automated solid-phase oligosaccharide synthesis allowed for the rapid synthesis of three Lewis-type cell surface oligosaccharides. The assembly of the nonasaccharide adenocarcinoma marker Le[superscript]y-Le[superscript]x monosaccharide building blocks was achieved in just 23 hours, while the syntheses of the tumor markers Lewis X, a pentasaccharide, and Lewis Y, a hexasaccharide, required only 12 and 14 hours respectively. The automation of carbohydrate synthesis greatly accelerates access to molecules for biological study and vaccine development.

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