Biochemistry of Arachidonic Acid Metabolism

Released on by William E.M. Lands
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  • Biochemistry of Arachidonic Acid Metabolism Book Detail

  • Author : William E.M. Lands
  • Release Date : 2012-12-06
  • Publisher : Springer Science & Business Media
  • Genre : Medical
  • Pages : 443
  • ISBN 13 : 1461325978
  • File Size : 70,70 MB
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Biochemistry of Arachidonic Acid Metabolism by William E.M. Lands PDF Summary

Book Description: Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec tively. Cyclooxygenase products consist of diverse products such as prosta glandin E, (POE,), prostacyclin (POI2) and thromboxane A2 (TXA2), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lip oxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.

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Arachidonic Acid in Cell Signaling

Arachidonic Acid in Cell Signaling

File Size : 42,42 MB
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This book is about the arachidonic acid cascade, its biochemistry, its pharmacology, and its roles in signal transduction. Arachidonic acid may serve as an intr