The Carbonic Anhydrases

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  • The Carbonic Anhydrases Book Detail

  • Author : W.R. Chegwidden
  • Release Date : 2013-11-11
  • Publisher : Birkhäuser
  • Genre : Science
  • Pages : 614
  • ISBN 13 : 303488446X
  • File Size : 69,69 MB

The Carbonic Anhydrases by W.R. Chegwidden PDF Summary

Book Description: Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This enzyme, which is present in at least three gene families (a, ß, ?), has found favour as a model for the study of evolution of gene families and for site-directed mutagenesis in structure/function relationships, for protein folding and for transgenic and gene target studies. Since the early use of CA inhibitors as diuretics and in treating congestive heart failure, the enzyme has been target of considerable clinical attention. Much of this is now focused on endeavours to produce a new generation of such drugs for the effective treatment of glaucoma and other potential applications. Recent data, suggesting links between CA and various disease processes, including cancer, have stimulated further...

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The Carbonic Anhydrases

The Carbonic Anhydrases

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Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis

Carbonic Anhydrase as Drug Target

Carbonic Anhydrase as Drug Target

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This book offers deep insights into the thermodynamics and molecular structures of the twelve catalytically active isoforms of human carbonic anhydrase (CA) wit

The Carbonic Anhydrases

The Carbonic Anhydrases

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