Chemo-enzymatic Synthesis of Sialosides Containing KDN Derivatives

Released on by Juan Arnaldo Guerrero
preview-18

  • Chemo-enzymatic Synthesis of Sialosides Containing KDN Derivatives Book Detail

  • Author : Juan Arnaldo Guerrero
  • Release Date : 2009
  • Publisher :
  • Genre :
  • Pages : 75
  • ISBN 13 : 9781109212860
  • File Size : 17,17 MB
DOWNLOAD BOOK

Chemo-enzymatic Synthesis of Sialosides Containing KDN Derivatives by Juan Arnaldo Guerrero PDF Summary

Book Description: Predominantly found as the outermost carbohydrate units on glycoproteins and glycolipids of vertebrates, sialic acids play vital roles in a variety of physiological and pathological processes. The ability of obtaining homogeneous sialosides, especially those containing various modifications on sialic acids, is of great interest for studies on the mechanism and significance of sialic acid structural diversity. This thesis presents a practical and efficient approach to the synthesis of important sialosides containing various KDN modifications, which are useful compounds for testing biological functions of sialoside derivatives. The research consists of two main sections: (1) chemical synthesis of mannose derivatives, and (2) enzymatic synthesis of sialosides containing KDN and its derivatives using synthetic mannose derivatives as sialic acid precursors. Seven mannose derivatives with a fluoro-, methyl-, or azido-functional group on different positions of the mannose backbone, have been chemically synthesized. These compounds have been employed to investigate the substrate specificities of sialoside' biosynthetic enzymes. A library of sialosides containing various KDN modifications has been obtained utilizing recent progress in efficient chemo-enzymatic synthesis of functionalized sialosides in a one-pot, three-enzyme developed in our laboratory.

Disclaimer: www.yourbookbest.com does not own Chemo-enzymatic Synthesis of Sialosides Containing KDN Derivatives books pdf, neither created or scanned. We just provide the link that is already available on the internet, public domain and in Google Drive. If any way it violates the law or has any issues, then kindly mail us via contact us page to request the removal of the link.