Design, Synthesis and Biological Evaluation of Histone Deacetylase (HDAC) Inhibitors

Released on by Ahmed Negmeldin
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  • Design, Synthesis and Biological Evaluation of Histone Deacetylase (HDAC) Inhibitors Book Detail

  • Author : Ahmed Negmeldin
  • Release Date : 2017
  • Publisher :
  • Genre : Biochemistry
  • Pages : 352
  • ISBN 13 :
  • File Size : 20,20 MB
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Design, Synthesis and Biological Evaluation of Histone Deacetylase (HDAC) Inhibitors by Ahmed Negmeldin PDF Summary

Book Description: The dual HDAC6/8 selective inhibitors can be used as lead compounds and as a chemical tool to study HDAC related cancer biology. The observed enhancement of selectivity upon modifying the linker region of the non-selective inhibitor SAHA shows that modifying current drugs, like SAHA, could lead to substantial improvement in its pharmacodynamic properties.

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