Excitotoxicity in Neurological Diseases

Released on by Carlo Ferrarese
preview-18

  • Excitotoxicity in Neurological Diseases Book Detail

  • Author : Carlo Ferrarese
  • Release Date : 2012-12-06
  • Publisher : Springer Science & Business Media
  • Genre : Medical
  • Pages : 358
  • ISBN 13 : 1441989595
  • File Size : 58,58 MB
DOWNLOAD BOOK

Excitotoxicity in Neurological Diseases by Carlo Ferrarese PDF Summary

Book Description: It can be reasonably anticipated that, over the next generations, the proportion of elderly people will remarkably increase and, with this, the number ofpersons suffering from acute (e.g. cerebral ischemia) or chronic neurodegenerative disorders. To date, approved drugs only alleviate the symptoms ofthese diseases (for instance, acetylcholinesterase inhibitors in Alzheimer disease and L-dopa and dopamine-agonists in Parkinson disease), while none seems to stop the progression of the degenerative processes underlying them. The development of effective preventive or protective therapies has been impeded by the limitations of our knowledge of the causes and the mechanisms by which neurons die in neurodegenerative disorders. Evidence accumulated in the past 20 years indicated that the major excitatory neurotransmitter glutamate may play a role as neurotoxin in several conditions. In particular, the glutamatergic system dysfunction seems to be an early event working as a common pathway in the pathogenesis ofa large number ofacute and chronic neurological disorders, in strict conjunction with other important mechanisms, such as oxidative stress and energetic failure, and probably triggered by different mechanisms in various diseases. In consideration of that, drug discovery efforts over the last decade have been focused on the search for drugs that either reduce glutamate synaptic levels or block its postsynaptic effects. Despite numerous reviews on basic mechanisms and clinical aspects ofthe excitotoxic phenomenon, so far no comprehensive book has covered the topic in all its complexity, starting from basic pharmacological mechanisms, to .animal models of diseases and finally to clinical pathogenic and therapeutic implications.

Disclaimer: www.yourbookbest.com does not own Excitotoxicity in Neurological Diseases books pdf, neither created or scanned. We just provide the link that is already available on the internet, public domain and in Google Drive. If any way it violates the law or has any issues, then kindly mail us via contact us page to request the removal of the link.

Excitotoxicity in Neurological Diseases

Excitotoxicity in Neurological Diseases

File Size : 95,95 MB
Total View : 4673 Views
DOWNLOAD

It can be reasonably anticipated that, over the next generations, the proportion of elderly people will remarkably increase and, with this, the number ofpersons

Neurochemical Aspects of Excitotoxicity

Neurochemical Aspects of Excitotoxicity

File Size : 61,61 MB
Total View : 4823 Views
DOWNLOAD

Leading researchers offer cutting-edge information on glutamate metabolism in the brain, examining the role of glutamate transporters and the involvement of glu