Exploring and Expanding the Protein Universe with Non-Canonical Amino Acids

Released on by Gustavo Fuertes
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  • Exploring and Expanding the Protein Universe with Non-Canonical Amino Acids Book Detail

  • Author : Gustavo Fuertes
  • Release Date : 2023-11-01
  • Publisher : Frontiers Media SA
  • Genre : Science
  • Pages : 123
  • ISBN 13 : 2832538029
  • File Size : 99,99 MB
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Exploring and Expanding the Protein Universe with Non-Canonical Amino Acids by Gustavo Fuertes PDF Summary

Book Description: The site-specific incorporation of unnatural or non-canonical amino acids (ncAAs) into proteins is a universally important tool for systems bioengineering at the interface of chemistry, biology, and biotechnology. The synergistic use of ncAA and related technologies (e.g. Xeno nucleic acids) should enable: i) New opportunities to manipulate, design and elucidate protein structure, dynamics, and function. ii) A deeper understanding of natural and evolved translational systems and their importance for artificial biology. iii) The synthesis of novel biopolymers, creating a solid basis for synthetic cells, which is also an important technology in the production of new classes of medically relevant protein-based scaffolds. Research on reprogrammed protein translation has now reached an experimental and intellectual maturity: more than 200 ncAA (i.e. more than ten times larger variety than standard amino acids) have been introduced into proteins using different routes: genetic code expansion (GCE), selective pressure incorporation (SPI), chemical mutagenesis, protein semi-synthesis, and peptide synthesis.

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The ability to introduce non-canonical amino acids in vivo has greatly expanded the repertoire of accessible proteins for basic research and biotechnological ap