From Biology to Clinical Management: An Update on Aortic Valve Disease. 2nd Edition

Released on by Cécile Oury
preview-18

  • From Biology to Clinical Management: An Update on Aortic Valve Disease. 2nd Edition Book Detail

  • Author : Cécile Oury
  • Release Date : 2020-03-04
  • Publisher : Frontiers Media SA
  • Genre :
  • Pages : 58
  • ISBN 13 : 2889633551
  • File Size : 36,36 MB
DOWNLOAD BOOK

From Biology to Clinical Management: An Update on Aortic Valve Disease. 2nd Edition by Cécile Oury PDF Summary

Book Description: Calcific aortic valve stenosis is the most frequent valvular heart disease in Western countries, affecting up to 13% of individuals over 75 years. The disease is associated with considerable morbidity and mortality. It is characterized by fibro-calcification of aortic valve cusps and concomitant left ventricular remodelling due to chronic pressure overload, which can evolve into overt heart failure. It progresses very slowly until the onset of symptoms, the indication for aortic valve replacement. Today, about 300,000 aortic valve replacements are performed annually worldwide, either via surgery or transcatheter implantation. This is the only treatment shown to improve survival. There is no pharmacological treatment to prevent or slow disease progression. Major risk factors include older age, congenital anomalies of the aortic valve (bicuspid valve), male gender, hypertension, dyslipidaemia, smoking, and diabetes. However, how these factors contribute to the disease in unclear. Due to the disease itself, patients are at increased risk of both thrombosis and bleeding, which, in addition to advanced age and comorbidities, makes antithrombotic management of these patients difficult. Regarding valve prostheses, the ideal prosthesis either mechanical or biological still does not exist. Clinically available prostheses can lead to major complications, thrombosis or infection, which necessitate reoperation or cause death in 50-60% of patients within 10 years post-implantation. Hence, there are major unmet medical needs in CAVS and more basic and translational research is definitely required. Our Research Topic depicts major challenges and research paths that could be followed to address these major health needs.

Disclaimer: www.yourbookbest.com does not own From Biology to Clinical Management: An Update on Aortic Valve Disease. 2nd Edition books pdf, neither created or scanned. We just provide the link that is already available on the internet, public domain and in Google Drive. If any way it violates the law or has any issues, then kindly mail us via contact us page to request the removal of the link.

Calcific Aortic Valve Disease

Calcific Aortic Valve Disease

File Size : 6,6 MB
Total View : 996 Views
DOWNLOAD

Due to population aging, calcific aortic valve disease (CAVD) has become the most common heart valve disease in Western countries. No therapies exist to slow th

Valvular Heart Disease

Valvular Heart Disease

File Size : 33,33 MB
Total View : 8168 Views
DOWNLOAD

Challenges for the treatment of valvular heart disease include the growing need for effective yet less invasive interventions and therapies to treat these progr