G Protein-Coupled Receptors in Drug Discovery

Released on by Wayne R. Leifert
preview-18

  • G Protein-Coupled Receptors in Drug Discovery Book Detail

  • Author : Wayne R. Leifert
  • Release Date : 2009-06-09
  • Publisher : Humana Press
  • Genre : Medical
  • Pages : 0
  • ISBN 13 : 9781603273169
  • File Size : 56,56 MB
DOWNLOAD BOOK

G Protein-Coupled Receptors in Drug Discovery by Wayne R. Leifert PDF Summary

Book Description: The G protein-coupled receptors (GPCRs) and associated peripheral G proteins underpin a multitude of physiological processes. The GPCRs represent one of the largest superfamilies in the human genome and are a significant target for bioactive and drug discovery programs. It is estimated that greater than 50% of all drugs, including those in development, currently target GPCRs. Many of the characterized GPCRs have known ligands; however, approximately 20% of GPCRs are described as orphan GPCRs, apparent GPCRs that share the generic high-level structure charact- istic of GPCRs but whose endogenous ligand is not known. Therefore, it is expected that the field of GPCR drug discovery and development will greatly expand in the coming years with emphasis on new generations of drugs against GPCRs with unique therapeuticuseswhichmayincludedrugssuchasallostericregulators,inverseagonists, and identification of orphan GPCR ligands. AswelearnmoreaboutthemolecularsignalingcascadesfollowingGPCRactivation, we acquire a better appreciation of the complexity of cell signaling and as a result, also acquire a vast array ofnew molecularmethods toinvestigate these andother processes. Thegeneralaimofthisbookistoprovideresearcherswitharangeofprotocolsthatmay be useful in their GPCR drug discovery programs. It is also the basis for the devel- ment of future assays in this field. Therefore, the range of topics covered and the appropriate methodological approaches in GPCR drug discovery are reflected in this book. Itisinterestingtonotethatfuturedirectionsindrugdiscoverywillrequireinput and collaboration from a plethora of fields of research. As such, this book will likely be of interest to scientists involved in such fields as molecular biology, pharmacology, biochemistry, cellular signaling, and bio-nanotechnology.

Disclaimer: www.yourbookbest.com does not own G Protein-Coupled Receptors in Drug Discovery books pdf, neither created or scanned. We just provide the link that is already available on the internet, public domain and in Google Drive. If any way it violates the law or has any issues, then kindly mail us via contact us page to request the removal of the link.

G Protein-Coupled Receptors as Drug Targets

G Protein-Coupled Receptors as Drug Targets

File Size : 19,19 MB
Total View : 6792 Views
DOWNLOAD

With its particular emphasis on the constitutive activity of G-protein-coupled receptors (GPCRs)s, this book comprehensively discusses an important biological p