Epigenetics of Aging

Released on by Trygve O. Tollefsbol
preview-18

  • Epigenetics of Aging Book Detail

  • Author : Trygve O. Tollefsbol
  • Release Date : 2009-11-11
  • Publisher : Springer Science & Business Media
  • Genre : Medical
  • Pages : 462
  • ISBN 13 : 1441906398
  • File Size : 53,53 MB
DOWNLOAD BOOK

Epigenetics of Aging by Trygve O. Tollefsbol PDF Summary

Book Description: Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.

Disclaimer: www.yourbookbest.com does not own Epigenetics of Aging books pdf, neither created or scanned. We just provide the link that is already available on the internet, public domain and in Google Drive. If any way it violates the law or has any issues, then kindly mail us via contact us page to request the removal of the link.

Epigenetics of Aging

Epigenetics of Aging

File Size : 61,61 MB
Total View : 6239 Views
DOWNLOAD

Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only

Aging of the Genome

Aging of the Genome

File Size : 75,75 MB
Total View : 1719 Views
DOWNLOAD

Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary

Genes, Aging, and Immortality

Genes, Aging, and Immortality

File Size : 3,3 MB
Total View : 1318 Views
DOWNLOAD

This booklet answers questions about the mysteries of aging and the search for immortality. It describes some of the current progress in the scientific study of

Longevity Genes

Longevity Genes

File Size : 94,94 MB
Total View : 1457 Views
DOWNLOAD

The release of the complete version of the human genome sequence in 2003 has paved the way for defining gene function and genetic background for phenotypic vari