Genome Instability in Cancer Development

Released on by Erich A. Nigg
preview-18

  • Genome Instability in Cancer Development Book Detail

  • Author : Erich A. Nigg
  • Release Date : 2006-01-14
  • Publisher : Springer Science & Business Media
  • Genre : Medical
  • Pages : 509
  • ISBN 13 : 1402037643
  • File Size : 46,46 MB
DOWNLOAD BOOK

Genome Instability in Cancer Development by Erich A. Nigg PDF Summary

Book Description: Research over the past decades has firmly established the genetic basis of cancer. In particular, studies on animal tumour viruses and chromosome rearrangements in human tumours have concurred to identify so-called ‘proto-oncogenes’ and ‘tumour suppressor genes’, whose deregulation promotes carcinogenesis. These important findings not only explain the occurrence of certain hereditary tumours, but they also set the stage for the development of anti-cancer drugs that specifically target activated oncogenes. However, in spite of tremendous progress towards the elucidation of key signalling pathways involved in carcinogenesis, most cancers continue to elude currently available therapies. This stands as a reminder that “cancer” is an extraordinarily complex disease: although some cancers of the haematopoietic system show only a limited number of characteristic chromosomal aberrations, most solid tumours display a myriad of genetic changes and considerable genetic heterogeneity. This is thought to reflect a trait commonly referred to as ‘genome instability’, so that no two cancers are ever likely to display the exact same genetic alterations. Numerical and structural chromosome aberrations were recognised as a hallmark of human tumours for more than a century. Yet, the causes and consequences of these aberrations still remain to be fully understood. In particular, the question of how genome instability impacts on the development of human cancers continues to evoke intense debate.

Disclaimer: www.yourbookbest.com does not own Genome Instability in Cancer Development books pdf, neither created or scanned. We just provide the link that is already available on the internet, public domain and in Google Drive. If any way it violates the law or has any issues, then kindly mail us via contact us page to request the removal of the link.

Genome Instability in Cancer Development

Genome Instability in Cancer Development

File Size : 90,90 MB
Total View : 6467 Views
DOWNLOAD

Research over the past decades has firmly established the genetic basis of cancer. In particular, studies on animal tumour viruses and chromosome rearrangements

Genome Stability

Genome Stability

File Size : 54,54 MB
Total View : 3031 Views
DOWNLOAD

Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genom

Systems Biology of Cancer

Systems Biology of Cancer

File Size : 10,10 MB
Total View : 5859 Views
DOWNLOAD

An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Genome Chaos

Genome Chaos

File Size : 52,52 MB
Total View : 3245 Views
DOWNLOAD

Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine transports readers from Mendelian Genetics to 4D-genomics, building a case for genes and ge