Immunotherapy and Small Molecule Inhibitors as Combinational Cancer Therapeutics

Released on by Mohd Wajid Ali Khan
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  • Immunotherapy and Small Molecule Inhibitors as Combinational Cancer Therapeutics Book Detail

  • Author : Mohd Wajid Ali Khan
  • Release Date : 2023-09-26
  • Publisher : Frontiers Media SA
  • Genre : Medical
  • Pages : 234
  • ISBN 13 : 2832534171
  • File Size : 42,42 MB
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Immunotherapy and Small Molecule Inhibitors as Combinational Cancer Therapeutics by Mohd Wajid Ali Khan PDF Summary

Book Description: Cancer is a multifactorial chronic disease, in which several factors contribute to its pathogenesis and progression. Our immune system is designed to continuously identify and destroy tumor or aberrant cells. However, a compromised immune system has been associated with the development of cancer. In such immune state, cancer cells often develop the ability to hide from the immune surveillance network and adopt intelligent survival tactics which are continuously developing. Therefore, researchers are focusing on boosting anti-tumor immunity by developing novel cancer immunotherapies. Adoptive cell-based cancer therapies are being used, including in vitro expansion and activation of immune effector cells and transfer to the patients. Tumor cells can be eliminated either by directly targeting the tumor cells or by enhancing various functions of the immune system. Other than CD8+ and NK cell-based cytotoxic cancer cell killing, there are antigen-presenting cells (APCs) such as dendritic, macrophages, B cells, and γδ T cells, which aggressively participate in the activation of anti-tumor immune response against many different cancers (myeloma, lymphoma, colorectal, melanoma, breast, colon, prostate, and ovarian cancers).

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Cancer Immunotherapy

Cancer Immunotherapy

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Cancer is managed by surgery, radiation therapy, and systemic drug therapies. Drug therapies include endocrine manipulation, single- or multi-agent chemotherapy