Inducing Targeted Protein Degradation

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  • Inducing Targeted Protein Degradation Book Detail

  • Author : Philipp Cromm
  • Release Date : 2022-11-15
  • Publisher : John Wiley & Sons
  • Genre : Medical
  • Pages : 389
  • ISBN 13 : 3527836217
  • File Size : 93,93 MB

Inducing Targeted Protein Degradation by Philipp Cromm PDF Summary

Book Description: Inducing Targeted Protein Degradation Enables drug developers in academia and industry to expand the range of accessible drug targets through induced protein degradation Since the breakthrough of the PROTAC technology in 2015, targeted protein degradation has revolutionized drug discovery, enabling pharma companies to develop completely novel therapeutics. Inducing Targeted Protein Degradation is a timely guide to navigating the complexities of the subject and understanding its practical application, with an eye on expanding the druggable space. In Inducing Targeted Protein Degradation, readers will find the most recent information on: Cellular mechanisms of targeted protein degradation and current approaches to utilize these mechanisms for drug discovery A comparison of different induced degradation approaches, including PROTAC, molecular glues, LYTACs and ATTECs as well as additional post translational modifications Drug development aspects such as DMPK optimization and criteria for the selection of clinical candidates A discussion of the potential of targeted degradation for expanding the druggable space Inducing Targeted Protein Degradation will serve as a practice-oriented reference on induced protein degradation for drug discovery professionals and for researchers employing chemical biology approaches.

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Inducing Targeted Protein Degradation

Inducing Targeted Protein Degradation

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Inducing Targeted Protein Degradation Enables drug developers in academia and industry to expand the range of accessible drug targets through induced protein de

Targeted Protein Degradation

Targeted Protein Degradation

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This volume contains a collection of innovative techniques for studying targeted protein degradation. Chapters guide readers through heterobifunctional proteoly

Targeted Protein Degradation

Targeted Protein Degradation

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Targeted Protein Degradation, Volume 680 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting c