Intercellular and Intracellular Signaling During Leukocyte-mediated Melanoma Cell Transendothelial Migration

Released on by Hsin-Hsin Peng
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  • Intercellular and Intracellular Signaling During Leukocyte-mediated Melanoma Cell Transendothelial Migration Book Detail

  • Author : Hsin-Hsin Peng
  • Release Date : 2007
  • Publisher :
  • Genre :
  • Pages : 115
  • ISBN 13 : 9780549046417
  • File Size : 49,49 MB
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Intercellular and Intracellular Signaling During Leukocyte-mediated Melanoma Cell Transendothelial Migration by Hsin-Hsin Peng PDF Summary

Book Description: Taken together, we have shown that melanoma cells induce PMNs to secrete IL-8 through activation of NF-kappaB and suggest a model in which this interaction promotes a microenvironment that is favorable for metastasis. Moreover, by inducing the PLC-Ca2+ signaling pathway, melanoma cells disrupt endothelial junctions to breach the endothelium and promote transvascular homing of tumor cells. In addition to experimental approaches, a mathematic model has been established for studying the intracellular dynamics, such as Ca2+ signaling. The tool is beneficial for signaling pathway analysis and discovery.

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