The Role of Physical and Biological Gut Barriers in Modulating Crosstalk between the Microbiota and the Immune System

Released on by Marika Falcone
preview-18

  • The Role of Physical and Biological Gut Barriers in Modulating Crosstalk between the Microbiota and the Immune System Book Detail

  • Author : Marika Falcone
  • Release Date : 2024-07-29
  • Publisher : Frontiers Media SA
  • Genre : Medical
  • Pages : 190
  • ISBN 13 : 2832552382
  • File Size : 40,40 MB
DOWNLOAD BOOK

The Role of Physical and Biological Gut Barriers in Modulating Crosstalk between the Microbiota and the Immune System by Marika Falcone PDF Summary

Book Description: The intestine has several means for maintaining immune homeostasis and for avoiding inflammation despite massive antigenic stimulation by food components and by commensal bacteria residing in the gut mucosa. These mechanisms include physical and biological barriers such as (i) the intestinal epithelial barrier (IEB); (ii) the gut vascular barrier (GVB) and (iii) the mucus layer. In particular, the mucus layer does not simply act as a diffusion barrier but has important dynamic functions that regulate the type of commensal bacteria residing in the inner mucus layer, enabling the passage of food and bacterial products into the gut tissue and systemic circulation. Importantly, the mucosal layer also has key immune regulatory functions. A healthy mucus structure is fundamental for promoting the presence of beneficial commensal bacteria, such as the short-chain fatty acids (SCFA)-producing bacteria which are known to promote immune tolerance. Moreover, the mucus layer contains anti-microbial peptides (AMPs) and mucins that have key immune modulatory functions. The integrated response of these combined defense systems is fundamental for containing microbes and their products within the intestine; for avoiding their systemic spread and for suppressing their capacity to activate systemic immune and autoimmune responses.

Disclaimer: www.yourbookbest.com does not own The Role of Physical and Biological Gut Barriers in Modulating Crosstalk between the Microbiota and the Immune System books pdf, neither created or scanned. We just provide the link that is already available on the internet, public domain and in Google Drive. If any way it violates the law or has any issues, then kindly mail us via contact us page to request the removal of the link.

Gut Feelings

Gut Feelings

File Size : 46,46 MB
Total View : 3205 Views
DOWNLOAD

Why the microbiome--our rich inner ecosystem of microorganisms--may hold the keys to human health. We are at the dawn of a new scientific revolution. Our unders