Small Molecule DNA and RNA Binders

Released on by Martine Demeunynck
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  • Small Molecule DNA and RNA Binders Book Detail

  • Author : Martine Demeunynck
  • Release Date : 2006-03-06
  • Publisher : John Wiley & Sons
  • Genre : Science
  • Pages : 754
  • ISBN 13 : 3527605665
  • File Size : 36,36 MB
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Small Molecule DNA and RNA Binders by Martine Demeunynck PDF Summary

Book Description: The development of molecules that selectively bind to nucleic acids has provided many details about DNA and RNA recognition. The range of such substances, such as metal complexes, peptides, oligonucleotides and a wide array of synthetic organic compounds, is as manifold as the functions of nucleic acids. Nucleic acid recognition sequences are often found in the major or minor groove of a double strand, while other typical interactions include intercalation between base pairs or the formation of triple or quadruple helices. One example of a binding mode that has recently been proposed is end stacking on such complex structures as the telomere tetraplex. In this comprehensive book, internationally recognized experts describe in detail the important aspects of nucleic acid binding, and in so doing present impressive approaches to drug design. Since typical substances may be created naturally or synthetically, emphasis is placed on natural products, chemical synthesis, the use of combinatorial libraries, and structural characterization. The whole is rounded off by contributions on molecular modeling, as well as investigations into the way in which any given drug interacts with its nucleic acid recognition site.

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Small Molecule DNA and RNA Binders

Small Molecule DNA and RNA Binders

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The development of molecules that selectively bind to nucleic acids has provided many details about DNA and RNA recognition. The range of such substances, such

Progress in Heterocyclic Chemistry

Progress in Heterocyclic Chemistry

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This volume of Progress in Heterocyclic Chemistry (PHC) is the eleventh annual review of the literature, covering the work published on most of the important he