Molecular Mechanisms of Dendritic Cell-Mediated Immune Tolerance and Autoimmunity

Released on by Fang Zhou
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  • Molecular Mechanisms of Dendritic Cell-Mediated Immune Tolerance and Autoimmunity Book Detail

  • Author : Fang Zhou
  • Release Date : 2024-04-09
  • Publisher : Frontiers Media SA
  • Genre : Medical
  • Pages : 213
  • ISBN 13 : 2832547702
  • File Size : 61,61 MB
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Molecular Mechanisms of Dendritic Cell-Mediated Immune Tolerance and Autoimmunity by Fang Zhou PDF Summary

Book Description: Dendritic cells (DCs) play a critical role in immune system, as they are necessary both for innate and adaptive immunity. According to their function, dendritic cells can be classified in immune tolerogenic or inflammatory DCs. DCs have been shown to regulate T cell-mediated immune responses and lead to immune tolerance and autoimmunity. For example, immune-tolerogenic DCs facilitate the development of regulatory T cells and inhibit T helper 17-mediated autoimmunity in mice with experimental autoimmune encephalomyelitis. Moreover, inflammatory DCs activate CD8+ and CD4+ T cells and elicit T cell-mediated inflammatory immune responses in vivo. However, the molecular and cellular mechanisms underlying DC-mediated immune tolerance and autoimmunity are still obscure.

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