Multiple Testing Procedures with Applications to Genomics

Released on by Sandrine Dudoit
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  • Multiple Testing Procedures with Applications to Genomics Book Detail

  • Author : Sandrine Dudoit
  • Release Date : 2010-11-25
  • Publisher : Springer
  • Genre : Science
  • Pages : 0
  • ISBN 13 : 9781441923790
  • File Size : 69,69 MB
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Multiple Testing Procedures with Applications to Genomics by Sandrine Dudoit PDF Summary

Book Description: This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments; tests of association between gene expression measures and biological annotation metadata; sequence analysis; and genetic mapping of complex traits using single nucleotide polymorphisms. The procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions, null hypotheses, and test statistics.

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