Neuroprotective Strategies for Traumatic Brain Injury

Released on by Terry Yin
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  • Neuroprotective Strategies for Traumatic Brain Injury Book Detail

  • Author : Terry Yin
  • Release Date : 2014
  • Publisher :
  • Genre : Neuroprotective agents
  • Pages : 134
  • ISBN 13 :
  • File Size : 54,54 MB
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Neuroprotective Strategies for Traumatic Brain Injury by Terry Yin PDF Summary

Book Description: The mechanism of P7C3 neuroprotection may be linked to its ability to activate the enzyme, nicotinamide phosphoribosyltransferase, which catalyzed the rate limiting step of nicotinamide adenine dinucleotide salvage pathway. Administration of the lead compound in the series, P7C3-S243, 1 day after blast-mediated TBI blocked axonal degeneration and preserved normal synaptic activity. P7C3-S243 administration also reduced neuronal functional deficits, including impaired learning, memory, and motor coordination in mice. We additionally reported persistent neurologic deficits and acquisition of anxiety-like phenotype in untreated animals 8-months after blast-mediated TBI. Optimized variants of P7C3 thus offer hope for identifying neuroprotective agents for conditions involving axonal damage, neuronal cell death, or both. Together, the results of this body of work identify novel therapeutic interventions that may attenuate deficits associated with TBI, and thus improve the quality of life in people after TBI.

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