On the Role of Delays in Biological Systems

Released on by Marcella Mary Gomez
preview-18

  • On the Role of Delays in Biological Systems Book Detail

  • Author : Marcella Mary Gomez
  • Release Date : 2015
  • Publisher :
  • Genre : Biological control systems
  • Pages : 220
  • ISBN 13 :
  • File Size : 70,70 MB
DOWNLOAD BOOK

On the Role of Delays in Biological Systems by Marcella Mary Gomez PDF Summary

Book Description: This work quantifies the nature of delays in genetic regulatory networks and their effect on system dynamics. It is known that a time lag can emerge from a sequence of biochemical reactions. Applying this modeling framework to the protein production processes, delay distributions are derived in a stochastic (probability density function) and deterministic setting (impulse function), whilst being shown to be equivalent under different assumptions. The dependence of the distribution properties on rate constants, gene length, and time-varying temperatures is investigated. Overall, the distribution of the delay in the context of protein production processes is shown to be highly dependent on the size of the genes and mRNA strands as well as the reaction rates. Results suggest longer genes have delay distributions with a smaller relative variance, and hence, less uncertainty in the completion times, however, they lead to larger delays. On the other hand large uncertainties may actually play a positive role, as broader distributions can lead to larger stability regions when this formalization of the protein production delays is incorporated into a feedback system. Furthermore, evidence suggests that delays may play a role as an explicit design into existing controlling mechanisms. Accordingly, the reccurring dual-feedback motif is also investigated with delays incorporated into the feedback channels. The dual-delayed feedback is shown to have stabilizing effects through a control theoretic approach. Lastly, a distributed delay based controller design method is proposed as a potential design tool. In a preliminary study, the dual-delayed feedback system re-emerges as an effective controller design.

Disclaimer: www.yourbookbest.com does not own On the Role of Delays in Biological Systems books pdf, neither created or scanned. We just provide the link that is already available on the internet, public domain and in Google Drive. If any way it violates the law or has any issues, then kindly mail us via contact us page to request the removal of the link.

On the Role of Delays in Biological Systems

On the Role of Delays in Biological Systems

File Size : 78,78 MB
Total View : 1118 Views
DOWNLOAD

This work quantifies the nature of delays in genetic regulatory networks and their effect on system dynamics. It is known that a time lag can emerge from a sequ

Biological Delay Systems

Biological Delay Systems

File Size : 16,16 MB
Total View : 3327 Views
DOWNLOAD

In studying the dynamics of populations, whether of animals, plants or cells, it is crucial to allow for delays such as those due to gestation, maturation or tr

Biological Delay Systems

Biological Delay Systems

File Size : 49,49 MB
Total View : 2332 Views
DOWNLOAD

In studying the dynamics of populations, whether of animals, plants or cells, it is crucial to allow for intrinsic delays, due to such things as gestation, matu

Time-delay Systems

Time-delay Systems

File Size : 60,60 MB
Total View : 8017 Views
DOWNLOAD

Time-delay occurs in many physical, industrial and engineering systems such as biological systems, chemical systems, metallurgical processing systems, nuclear r