Origin and spatiotemporal dynamics of the peroxisomal endomembrane system

Released on by Vladimir I Titorenko
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  • Origin and spatiotemporal dynamics of the peroxisomal endomembrane system Book Detail

  • Author : Vladimir I Titorenko
  • Release Date : 2015-03-05
  • Publisher : Frontiers Media SA
  • Genre : Physiology
  • Pages : 149
  • ISBN 13 : 2889194647
  • File Size : 89,89 MB
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Origin and spatiotemporal dynamics of the peroxisomal endomembrane system by Vladimir I Titorenko PDF Summary

Book Description: The peroxisome is an organelle with essential roles in lipid metabolism, maintenance of reactive oxygen species homeostasis, and anaplerotic replenishment of tricarboxylic acid cycle intermediates destined for mitochondria. Peroxisomes constitute a dynamic endomembrane system. The homeostatic state of this system is upheld via two pathways for assembling and maintaining the diverse peroxisomal compartments constituting it; the relative contribution of each pathway to preserving such system may vary in different organisms and under various physiological conditions. One pathway begins with the targeting of certain peroxisomal membrane proteins to an endoplasmic reticulum template and their exit from the template via pre-peroxisomal carriers; these carriers mature into metabolically active peroxisomes containing the entire complement of membrane and matrix proteins. Another pathway operates via growth and maturation of pre-existing peroxisomal precursors that do not originate from the endoplasmic reticulum; mature peroxisomes proliferate by undergoing fission. Recent studies have uncovered new roles for the peroxisomal endomembrane system in orchestrating important developmental decisions and defining organismal longevity. This Frontiers Special Topic Issue is focused on the advances in our understanding of how evolutionarily distant organisms coordinate the formation, maturation, proliferation, maintenance, inheritance and quality control of the peroxisomal endomembrane system and how peroxisomal endomembranes communicate with other cellular compartments to orchestrate complex biological processes and various developmental programs from inside the cell.

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Cellular Mechanics and Biophysics

Cellular Mechanics and Biophysics

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This book focuses on the mechanical properties of cells, discussing the basic concepts and processes in the fields of immunology, biology, and biochemistry. It