Peptide Transport and Delivery into the Central Nervous System

Released on by Laszlo Prokai
preview-18

  • Peptide Transport and Delivery into the Central Nervous System Book Detail

  • Author : Laszlo Prokai
  • Release Date : 2012-12-06
  • Publisher : Birkhäuser
  • Genre : Medical
  • Pages : 250
  • ISBN 13 : 3034880499
  • File Size : 9,9 MB
DOWNLOAD BOOK

Peptide Transport and Delivery into the Central Nervous System by Laszlo Prokai PDF Summary

Book Description: Hypo- or hypersecretion, alteration in storage, release, catabolism, and post-translational processing of neuropeptides are associated with the etiology of many diseases affecting the central nervous system (CNS). Various peptides native to the brain and the spinal cord, as well as various synthetic peptides, peptide analogues and peptidomimetics developed as their agonists or antagonists could be useful in the treatment of these CNS maladies. However, peptides face a formidable obstacle in reaching the intended site of action due to the existence of the blood-brain barrier (BBB), a vital element in the regulation of the internal environment of the brain and the spinal cord. After reviews on the role and neuropharmaceutical potential of peptides, properties of the BBB in the context of peptide transport in the CNS and potential transport mechanisms to cross the BBB, this volume discusses the development, present state-of-the-art and future trends of various strategies to overcome this major obstacle to peptide pharmacotherapy involving the CNS. Chapters are devoted to cover invasive approaches that circumvent the BBB by direct administration into the brain or the spinal cord and by transiently opening the tight junctions of or permeabilizing the endothelial cells separating the systemic circulation from the interstitial fluid of the CNS. Subsequently, physiologically based strategies that utilize biological carriers to gain access to the CNS are discussed in detail, followed by methods encompassing prodrug and chemical delivery/targeting strategies, which aim at altering the properties of the peptide to enhance BBB transport, and drug delivery strategies based on peptide vectors. Finally, a comparative evaluation on the present status and perspectives of the techniques is presented.

Disclaimer: www.yourbookbest.com does not own Peptide Transport and Delivery into the Central Nervous System books pdf, neither created or scanned. We just provide the link that is already available on the internet, public domain and in Google Drive. If any way it violates the law or has any issues, then kindly mail us via contact us page to request the removal of the link.

Drug Delivery to the Central Nervous System

Drug Delivery to the Central Nervous System

File Size : 60,60 MB
Total View : 5701 Views
DOWNLOAD

Playing an important role in the treatment of neurological disorders, the delivery of drugs to central nervous system (CNS), both administered directly and admi

Drug Delivery to the Brain

Drug Delivery to the Brain

File Size : 72,72 MB
Total View : 7414 Views
DOWNLOAD

The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, t

Blood-Brain Barrier

Blood-Brain Barrier

File Size : 24,24 MB
Total View : 2326 Views
DOWNLOAD

The vasculature of the central nervous system (eNS) is characterized by the existence of the blood-brain barrier (BBB), which can be regarded as both an anatomi