Phosphodiesterases and Their Inhibitors

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  • Phosphodiesterases and Their Inhibitors Book Detail

  • Author : Spiros Liras
  • Release Date : 2014-03-03
  • Publisher : John Wiley & Sons
  • Genre : Medical
  • Pages : 280
  • ISBN 13 : 3527682368
  • File Size : 44,44 MB

Phosphodiesterases and Their Inhibitors by Spiros Liras PDF Summary

Book Description: Written by the pioneers of Viagra, the first blockbuster PDE inhibitor drug. Beginning with a review of the first wave of phosphodiesterase (PDE) inhibitors, this book focuses on new and emerging PDE targets and their inhibitors. Drug development options for all major human PDE families are discussed and cover diverse therapeutic fields, such as neurological/psychiatric, cardiovascular/metabolic, pain, and allergy/respiratory diseases. Finally, emerging chemotherapeutic applications of PDE inhibitors against malaria and other tropical diseases are discussed.

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Phosphodiesterases and Their Inhibitors

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Phosphodiesterase Inhibitors

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Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been used extensively since 1958. In the decade of the '70s, v