Phosphodiesterases: CNS Functions and Diseases

Released on by Han-Ting Zhang
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  • Phosphodiesterases: CNS Functions and Diseases Book Detail

  • Author : Han-Ting Zhang
  • Release Date : 2017-09-26
  • Publisher : Springer
  • Genre : Medical
  • Pages : 475
  • ISBN 13 : 3319588117
  • File Size : 10,10 MB
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Phosphodiesterases: CNS Functions and Diseases by Han-Ting Zhang PDF Summary

Book Description: PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic nucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthritis. This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer's Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases. The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.

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PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic neucleotides. They are implicated in a number of disorders and dysfunctions an

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Phosphodiesterases and Their Inhibitors

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Written by the pioneers of Viagra, the first blockbuster PDE inhibitor drug. Beginning with a review of the first wave of phosphodiesterase (PDE) inhibitors, th