Protein Tyrosine Kinases

Released on by Doriano Fabbro
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  • Protein Tyrosine Kinases Book Detail

  • Author : Doriano Fabbro
  • Release Date : 2007-11-13
  • Publisher : Springer Science & Business Media
  • Genre : Science
  • Pages : 599
  • ISBN 13 : 1592599621
  • File Size : 8,8 MB
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Protein Tyrosine Kinases by Doriano Fabbro PDF Summary

Book Description: Leading researchers, from the Novartis group that pioneered Gleevec/GlivecTM and around the world, comprehensively survey the state of the art in the drug discovery processes (bio- and chemoinformatics, structural biology, profiling, generation of resistance, etc.) aimed at generating PTK inhibitors for the treatment of various diseases, including cancer. Highlights include a discussion of the rationale and the progress made towards generating "selective" low molecular-weight kinase inhibitors; an analysis of the normal function, role in disease, and application of platelet-derived growth factor antagonists; and a summary of the factors involved in successful structure-based drug design. Additional chapters address the advantages and disadvantages of in vivo preclinical models for testing protein kinase inhibitors with antitumor activity and the utility of different methods in the drug discovery and development process for determining "on-target" vs "off-target" effects of kinase inhibitors.

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Protein Tyrosine Kinases

Protein Tyrosine Kinases

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Leading researchers, from the Novartis group that pioneered Gleevec/GlivecTM and around the world, comprehensively survey the state of the art in the drug disco

Signaling by Receptor Tyrosine Kinases

Signaling by Receptor Tyrosine Kinases

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Receptor tyrosine kinases are cell-surface receptors that respond to numerous hormones and growth factors, including insulin, insulin-like growth factors, epide