Molecular Aspects of G Protein-coupled Receptors

Released on by Francisco Ciruela
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  • Molecular Aspects of G Protein-coupled Receptors Book Detail

  • Author : Francisco Ciruela
  • Release Date : 2008
  • Publisher : Nova Publishers
  • Genre : Science
  • Pages : 328
  • ISBN 13 : 9781600219153
  • File Size : 50,50 MB
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Molecular Aspects of G Protein-coupled Receptors by Francisco Ciruela PDF Summary

Book Description: In the recent years, studies based on two-hybrid screens, proteomic, biochemical and cell biology approaches, have shown that intracellular domains of G protein-coupled receptors (GPCR) or heptaspanning membrane receptors (HSMRs) interact with intracellular proteins. These interactions are the basis of a protein network associated to these receptors which includes scaffolding proteins containing one or several PDZ (post-synaptic density-95, discs large, zona occludens-1) domains, signalling proteins and proteins of the cytoskeleton. The present book is focused on the emerging evidence for interactions of G protein-coupled receptors with scaffolding, cytoskeletal and signalling proteins that will play a role in the targeting, anchoring and functioning of these receptors in the plasma membrane, thus contributing to cell development and plasticity.

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