Regulation of Cancer Immune Checkpoints

Released on by
preview-18

  • Regulation of Cancer Immune Checkpoints Book Detail

  • Author :
  • Release Date : 2020
  • Publisher :
  • Genre : Cancer
  • Pages : 657
  • ISBN 13 : 9789811532672
  • File Size : 26,26 MB
DOWNLOAD BOOK

Regulation of Cancer Immune Checkpoints by PDF Summary

Book Description: This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic. The past decade has seen major advances in cancer immune checkpoint therapy, which has demonstrated impressive clinical benefits. The family of checkpoints for mediating cancer immune evasion now includes CTLA-4, PD-1/PD-L1, CD27/CD70, FGL-1/LAG-3, Siglec-15, VISTA (PD-1L)/VSIG3, CD47/SIRPA, APOE/LILRB4, TIGIT, and many others. Despite these strides, most patients do not show lasting remission, and some cancers have been completely resistant to the therapy. The potentially lethal adverse effects of checkpoint blockade represent another major challenge, the mechanisms of which remain poorly understood. Compared to the cancer signaling pathways, such as p53 and Ras, mechanistic studies on immune checkpoint pathways are still in their infancy. To improve the responses to checkpoint blockade therapy and limit the adverse effects, it is essential to understand the molecular regulation of checkpoint molecules in both malignant and healthy cells/tissues. This book begins with an introduction to immune checkpoint therapy and its challenges, and subsequently describes the regulation of checkpoints at different levels. In closing, it discusses recent therapeutic developments based on mechanistic findings, and outlines goals for future translational studies. The book offers a valuable resource for researchers in the cancer immunotherapy field, helping to form a roadmap for checkpoint regulation and develop safer and more effective immunotherapies.

Disclaimer: www.yourbookbest.com does not own Regulation of Cancer Immune Checkpoints books pdf, neither created or scanned. We just provide the link that is already available on the internet, public domain and in Google Drive. If any way it violates the law or has any issues, then kindly mail us via contact us page to request the removal of the link.

Regulation of Cancer Immune Checkpoints

Regulation of Cancer Immune Checkpoints

File Size : 14,14 MB
Total View : 3824 Views
DOWNLOAD

This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely une

Regulation of Cancer Immune Checkpoints

Regulation of Cancer Immune Checkpoints

File Size : 63,63 MB
Total View : 5373 Views
DOWNLOAD

This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely une

Immune Checkpoint Inhibitors in Cancer

Immune Checkpoint Inhibitors in Cancer

File Size : 85,85 MB
Total View : 3340 Views
DOWNLOAD

Get a quick, expert overview of the latest clinical information and guidelines for cancer checkpoint inhibitors and their implications for specific types of can