Regulatory Networks in Stem Cells

Released on by Vinagolu K. Rajasekhar
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  • Regulatory Networks in Stem Cells Book Detail

  • Author : Vinagolu K. Rajasekhar
  • Release Date : 2009-03-04
  • Publisher : Springer Science & Business Media
  • Genre : Medical
  • Pages : 590
  • ISBN 13 : 1603272275
  • File Size : 1,1 MB
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Regulatory Networks in Stem Cells by Vinagolu K. Rajasekhar PDF Summary

Book Description: Stem cells appear to be fundamental cellular units associated with the origin of multicellular organisms and have evolved to function in safeguarding the cellular homeostasis in organ t- sues. The characteristics of stem cells that distinguish them from other cells have been the fascinating subjects of stem cell research. The important properties of stem cells, such as ma- tenance of quiescence, self-renewal capacity, and differentiation potential, have propelled this exciting ?eld and presently form a common theme of research in developmental biology and medicine. The derivation of pluripotent embryonic stem cells, the prospective identi?cation of multipotent adult stem cells, and, more recently, the induced pluripotent stem cells (popularly called iPS) are important milestones in the arena of stem cell biology. Complex networks of transcription factors, different signaling molecules, and the interaction of genetic and epi- netic events constantly modulate stem cell behavior to evoke programming and reprogramming processes in normal tissue homeostasis during development. In any given cellular scenario, the regulatory networks can pose considerable complexity and yet exert an orderly control of stem cell differentiation during normal development. An aberration in these ?nely tuned processes during development usually results in a spectrum of diseases such as cancers and neurological disorders. Thisunderscorestheimminentneedforamorecompleteunderstandingofmolecular mechanisms underlying the regulatory circuitries required for stem cell maintenance. Overthepast3–5years,adiversegroupofbenchandphysicianscientistshaveprospectively enhanced our knowledge of stem cell biology. These studies are unveiling many unrecognized or previously unknown fundamentals of developmental biology.

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Regulatory Networks in Stem Cells

Regulatory Networks in Stem Cells

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Stem cells appear to be fundamental cellular units associated with the origin of multicellular organisms and have evolved to function in safeguarding the cellul

Regulatory Networks in Stem Cells

Regulatory Networks in Stem Cells

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Stem cells appear to be fundamental cellular units associated with the origin of multicellular organisms and have evolved to function in safeguarding the cellul

The Cell Biology of Stem Cells

The Cell Biology of Stem Cells

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Stem cells have been gaining a lot of attention in recent years. Their unique potential to self-renew and differentiate has turned them into an attractive model