Structural Biology in Drug Discovery

Released on by Jean-Paul Renaud
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  • Structural Biology in Drug Discovery Book Detail

  • Author : Jean-Paul Renaud
  • Release Date : 2020-01-09
  • Publisher : John Wiley & Sons
  • Genre : Medical
  • Pages : 1367
  • ISBN 13 : 1118900502
  • File Size : 13,13 MB
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Structural Biology in Drug Discovery by Jean-Paul Renaud PDF Summary

Book Description: With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

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Structural Biology in Drug Discovery

Structural Biology in Drug Discovery

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With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biolog

Structural Biology in Drug Discovery

Structural Biology in Drug Discovery

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With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biolog

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The last decade has seen the confluence of several enabling technologies that have allowed protein crystallographic methods to live up to their true potential.

Structure-based Drug Discovery

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This book describes some of the most exciting developments for the discovery of new drugs, such as Fragment-based methods. It contains the latest developments i