Centromere

Released on by Durdica Ugarkovic
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  • Centromere Book Detail

  • Author : Durdica Ugarkovic
  • Release Date : 2009-06-12
  • Publisher : Springer Science & Business Media
  • Genre : Science
  • Pages : 191
  • ISBN 13 : 3642001823
  • File Size : 58,58 MB
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Centromere by Durdica Ugarkovic PDF Summary

Book Description: The centromere is a chromosomal region that enables the accurate segregation of chromosomes during mitosis and meiosis. It holds sister chromatids together, and through its centromere DNA–protein complex known as the kinetochore binds spindle microtubules to bring about accurate chromosome movements. Despite this conserved function, centromeres exhibit dramatic difference in structure, size, and complexity. Extensive studies on centromeric DNA revealed its rapid evolution resulting often in significant difference even among closely related species. Such a plasticity of centromeric DNA could be explained by epigenetic c- trol of centromere function, which does not depend absolutely on primary DNA sequence. According to epigenetic centromere concept, which is thoroughly d- cussed by Tanya Panchenko and Ben Black in Chap. 1 of this book, centromere activation or inactivation might be caused by modifications of chromatin. Such acquired chromatin epigenetic modifications are then inherited from one cell di- sion to the next. Concerning centromere-specific chromatin modification, it is now evident that all centromeres contain a centromere specific histone H3 variant, CenH3, which replaces histone H3 in centromeric nucleosomes and provides a structural basis that epigenetically defines centromere and differentiates it from the surrounding chromatin. Recent insights into the CenH3 presented in this chapter add important mechanistic understanding of how centromere identity is initially established and subsequently maintained in every cell cycle.

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Centromere

Centromere

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The centromere is a chromosomal region that enables the accurate segregation of chromosomes during mitosis and meiosis. It holds sister chromatids together, and

The Centromere

The Centromere

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The centromere is an essential structure on all eukaryotic chromosomes that allows the equipartition of chromosomes during mitotic and meiotic cell divisions. S

Centromeres and Kinetochores

Centromeres and Kinetochores

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This book presents the latest advances concerning the regulation of chromosome segregation during cell division by means of centromeres and kinetochores. The au

Plant Centromere Biology

Plant Centromere Biology

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Plant Centromere Biology is dedicated to plant centromere research. Chapters cover the structure of centromeres from several plant species including Arabidopsis

Chromatin Regulation and Dynamics

Chromatin Regulation and Dynamics

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Chromatin Regulation and Dynamics integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects rela