The Proprotein Convertases

Released on by Abdel-Majid Khatib
preview-18

  • The Proprotein Convertases Book Detail

  • Author : Abdel-Majid Khatib
  • Release Date : 2013-02
  • Publisher : Morgan & Claypool Publishers
  • Genre : Medical
  • Pages : 89
  • ISBN 13 : 1615045368
  • File Size : 88,88 MB
DOWNLOAD BOOK

The Proprotein Convertases by Abdel-Majid Khatib PDF Summary

Book Description: Proprotein convertases (PCs) are a family of proteases including PC1, PC2, Furin, PC4, PACE4, PC5, and PC7. These enzymes are involved in the maturation of many precursor proteins involved in the process of tumorigenesis and metastasis. Since their discovery, PCs were suggested as potential targets for anti-cancer therapy, and their activity was found to directly affect tumor cell proliferation, migration invasion, and the malignant phenotypes of tumor cells. Here, we discuss a number of previous and recent findings on the PCs features, their implication in the regulation of multiple cellular functions that impact on the invasive/metastatic potential of cancer cells, and their clinical relevance in cancer patients. Among the substrates of the proprotein convertases, various growth factors, their receptors, adhesion molecules, and proteases were identified. The PCs are inhibited by endogenous and exogenous inhibitors. To date, only pro7B2, a specific chaperone of PC2, and the granine-like precursor of neuroendocrine protein proSAAS, a selective ligand of PC1, have been identified as endogenous inhibitors of the PCs found in the regulated pathway. However, only PCs prosegments, several bioengineered inhibitors, peptides, and non-peptide compounds were found to inhibit the activity of the PCs found in the secretory pathway.

Disclaimer: www.yourbookbest.com does not own The Proprotein Convertases books pdf, neither created or scanned. We just provide the link that is already available on the internet, public domain and in Google Drive. If any way it violates the law or has any issues, then kindly mail us via contact us page to request the removal of the link.

Activation of Viruses by Host Proteases

Activation of Viruses by Host Proteases

File Size : 8,8 MB
Total View : 6568 Views
DOWNLOAD

This book will give an overview on viruses undergoing proteolytic activation through host proteases. The chapters will be organized in three themed parts, the f

Cardiology Secrets

Cardiology Secrets

File Size : 98,98 MB
Total View : 3932 Views
DOWNLOAD

Get quick answers to the most important clinical questions with Cardiology Secrets! Using the popular and trusted Secret Series(R) Q&A format, this easy-to-read

Statin-Associated Muscle Symptoms

Statin-Associated Muscle Symptoms

File Size : 91,91 MB
Total View : 8080 Views
DOWNLOAD

This book provides an overview of statin-associated muscle symptoms (SAMS) from clinical presentation to treatment and possible metabolic causes. It examines th