ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins

Released on by Honghui Zhou
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  • ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins Book Detail

  • Author : Honghui Zhou
  • Release Date : 2015-10-26
  • Publisher : John Wiley & Sons
  • Genre : Medical
  • Pages : 479
  • ISBN 13 : 111889880X
  • File Size : 64,64 MB
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ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins by Honghui Zhou PDF Summary

Book Description: With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. • Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs • Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective • Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines • Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan • Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain

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