Developments in T Cell Based Cancer Immunotherapies

Released on by Paolo A. Ascierto
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  • Developments in T Cell Based Cancer Immunotherapies Book Detail

  • Author : Paolo A. Ascierto
  • Release Date : 2015-11-26
  • Publisher : Humana Press
  • Genre : Medical
  • Pages : 315
  • ISBN 13 : 3319211676
  • File Size : 78,78 MB
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Developments in T Cell Based Cancer Immunotherapies by Paolo A. Ascierto PDF Summary

Book Description: This volume illustrates the salient aspects of cancer biology relevant to the successful implementation of immunotherapy. Topics include enhancement of antigen-specific immune responses by anti-cancer vaccines, modulation of the function of T cells within the tumor microenvironment, and the effects of genetic, epigenetic, developmental, and environmental determinants on T cell function. Other topics covered include the ex vivo expansion of T or other immune cells and their genetic modification or reprogramming to increase their ability to survive and expand when adoptively transferred back to the patients. Specific attention is devoted to the genetic manipulation of T cells through the introduction of re-directed T cell receptors, chimeric antibody receptors, and other genetic manipulation aimed at improving their effectiveness as anti-cancer agents. Furthermore, the revolutionary role of checkpoint inhibitors and their potential in combination with other immunotherapeutic approaches or with standard chemo and radiation therapy are extensively discussed.

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The War of the Rebellion

The War of the Rebellion

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Official records produced by the armies of the United States and the Confederacy, and the executive branches of their respective governments, concerning the mil