HIV-1 Broadly Neutralizing Antibody Precursor B Cells Revealed by Germline-targeting Immunogen

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  • HIV-1 Broadly Neutralizing Antibody Precursor B Cells Revealed by Germline-targeting Immunogen Book Detail

  • Author :
  • Release Date : 2016
  • Publisher :
  • Genre :
  • Pages : 6
  • ISBN 13 :
  • File Size : 49,49 MB
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HIV-1 Broadly Neutralizing Antibody Precursor B Cells Revealed by Germline-targeting Immunogen by PDF Summary

Book Description: Induction of broadly neutralizing antibodies (bnAbs) is a major HIV vaccine goal. Germline-targeting immunogens aim to initiate bnAb induction by activating bnAb germline precursor B cells. Critical unmet challenges are to determine whether bnAb precursor naïve B cells bind germline-targeting immunogens and occur at sufficient frequency in humans for reliable vaccine responses. We employed deep mutational scanning and multi-target optimization to develop a germline-targeting immunogen (eOD-GT8) for diverse VRC01-class bnAbs. We then used the immunogen to isolate VRC01-class precursor naïve B cells from HIV-uninfected donors. Frequencies of true VRC01-class precursors, their structures, and their eOD-GT8 affinities support this immunogen as a candidate human vaccine prime. Lastly, these methods could be applied to germline targeting for other classes of HIV bnAbs and for Abs to other pathogens.

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