Immune Involvement in Recurrent Pregnancy Loss

Released on by Gendie Lash
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  • Immune Involvement in Recurrent Pregnancy Loss Book Detail

  • Author : Gendie Lash
  • Release Date : 2023-11-27
  • Publisher : Frontiers Media SA
  • Genre : Medical
  • Pages : 119
  • ISBN 13 : 2832539793
  • File Size : 70,70 MB
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Immune Involvement in Recurrent Pregnancy Loss by Gendie Lash PDF Summary

Book Description: Recurrent pregnancy loss (RPL) is defined as two or more consecutive pregnancy losses before the 20th week of gestation, occuring in 1%–3% of reproductive women. Unexplained RPL (URPL) is a heterogeneous condition affecting approximately 50% of RPL cases, with one contributing factor thought to be a disruption in maternal immune tolerance. Various immune effectors and molecules in the immune-microenvironment establish specific maternal tolerance toward the semi-allogeneic fetus during pregnancy. Immune cells including innate lymphoid cells (ILCs), myeloid cells, T cells and B cells have been found to contribute to maintaining this maternal immunological tolerance during pregnancy. ILCs have been found to be the most abundant immune cells in the pregnant uterus, with many studies focusing on the relationship between RPL and either T cells or natural killer (NK) cells in peripheral blood and the endometrium/decidua. Despite progress in uncovering the roles of NK, and regulatory T cells and cytokines in pregnancy, the immune heterogeneity in patients with URPL remains elusive.

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