Handbook of Statistical Methods for Randomized Controlled Trials

Released on by KyungMann Kim
preview-18

  • Handbook of Statistical Methods for Randomized Controlled Trials Book Detail

  • Author : KyungMann Kim
  • Release Date : 2021-08-23
  • Publisher : CRC Press
  • Genre : Mathematics
  • Pages : 655
  • ISBN 13 : 1498714641
  • File Size : 37,37 MB
DOWNLOAD BOOK

Handbook of Statistical Methods for Randomized Controlled Trials by KyungMann Kim PDF Summary

Book Description: Statistical concepts provide scientific framework in experimental studies, including randomized controlled trials. In order to design, monitor, analyze and draw conclusions scientifically from such clinical trials, clinical investigators and statisticians should have a firm grasp of the requisite statistical concepts. The Handbook of Statistical Methods for Randomized Controlled Trials presents these statistical concepts in a logical sequence from beginning to end and can be used as a textbook in a course or as a reference on statistical methods for randomized controlled trials. Part I provides a brief historical background on modern randomized controlled trials and introduces statistical concepts central to planning, monitoring and analysis of randomized controlled trials. Part II describes statistical methods for analysis of different types of outcomes and the associated statistical distributions used in testing the statistical hypotheses regarding the clinical questions. Part III describes some of the most used experimental designs for randomized controlled trials including the sample size estimation necessary in planning. Part IV describe statistical methods used in interim analysis for monitoring of efficacy and safety data. Part V describe important issues in statistical analyses such as multiple testing, subgroup analysis, competing risks and joint models for longitudinal markers and clinical outcomes. Part VI addresses selected miscellaneous topics in design and analysis including multiple assignment randomization trials, analysis of safety outcomes, non-inferiority trials, incorporating historical data, and validation of surrogate outcomes.

Disclaimer: www.yourbookbest.com does not own Handbook of Statistical Methods for Randomized Controlled Trials books pdf, neither created or scanned. We just provide the link that is already available on the internet, public domain and in Google Drive. If any way it violates the law or has any issues, then kindly mail us via contact us page to request the removal of the link.

Designs for Clinical Trials

Designs for Clinical Trials

File Size : 50,50 MB
Total View : 7586 Views
DOWNLOAD

This book will examine current issues and controversies in the design of clinical trials, including topics in adaptive and sequential designs, the design of cor