Metabolism of Cancer Cells and Immune Cells in the Tumor Microenvironment

Released on by Yongsheng Li
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  • Metabolism of Cancer Cells and Immune Cells in the Tumor Microenvironment Book Detail

  • Author : Yongsheng Li
  • Release Date : 2019-03-20
  • Publisher : Frontiers Media SA
  • Genre :
  • Pages : 87
  • ISBN 13 : 2889457850
  • File Size : 96,96 MB
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Metabolism of Cancer Cells and Immune Cells in the Tumor Microenvironment by Yongsheng Li PDF Summary

Book Description: Metabolism of glucose, lipids, amino acids, and nucleotides represents the fundamental capability of host to utilize distinct nutrients and energy to support diverse function of different cell lineages. Cancer cells undergo the Warburg Effect to adapt to the microenvironment composed by stromal cells and immune cells. The crosstalk among cancer cells and immune cells orchestrate tumor progression. In the tumor microenvironment, immune cells also show metabolic reprogramming. For example, naive or memory T cells switch from the oxidation of fatty acids to glycolysis and glutaminolysis after activation; meanwhile massive glucose and glutamine are transported into cells to meet their metabolic demands. Defective glucose or glutamine metabolism impairs the differentiation and expansion of helper T cells. The molecular pathways that control immune cell metabolism and function are intimately linked. Understanding such metabolic reprogramming of immune cells in the tumor microenvironment could offer new directions in manipulation of peripheral immune responses. Recent findings in immune cell metabolism hold the promising possibilities by metabolic manipulation of immune cells towards clinical therapeutics for treating cancer. This Research Topic includes updated findings and views in the metabolism of cancer cells and immune cells in the tumor microenvironment.

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