Metals in Biology

Released on by Graeme Hanson
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  • Metals in Biology Book Detail

  • Author : Graeme Hanson
  • Release Date : 2010-03-11
  • Publisher : Springer
  • Genre : Medical
  • Pages : 427
  • ISBN 13 : 1441911391
  • File Size : 46,46 MB
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Metals in Biology by Graeme Hanson PDF Summary

Book Description: Metal ions in biology is an ever expanding area in science and medicine involving metal ions in proteins and enzymes, their biosynthesis, catalysis, electron transfer, metal ion trafficking, gene regulation and disease. While X-ray crystallography has provided snapshots of the geometric structures of the active site redox cofactors in these proteins, the application of high resolution EPR spectroscopy in conjunction with quantum chemistry calculations has enabled, in many cases, a detailed understanding of a metalloenzymes mechanism through investigations of the geometric and electronic structure of the resting, enzyme-substrate intermediates and product complexes. This volume, Part II of a two-volume set demonstrates the application of high resolution EPR spectroscopy in determining the geometric and electronic structure of active site metal ion centers in iron sulfur cluster containing metalloproteins, mononuclear molybdenum metalloenzymes, manganese-containing enzymes and novel metalloproteins.

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