NMR with Biological Macromolecules in Solution

Released on by Kurt Wüthrich
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  • NMR with Biological Macromolecules in Solution Book Detail

  • Author : Kurt Wüthrich
  • Release Date : 2021
  • Publisher : World Scientific Publishing Company
  • Genre : Science
  • Pages : 270
  • ISBN 13 : 9789811235788
  • File Size : 63,63 MB
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NMR with Biological Macromolecules in Solution by Kurt Wüthrich PDF Summary

Book Description: The book provides insights into the research of the Kurt Wüthrich laboratories from 1996-2020. During this time period, the technique of nuclear magnetic resonance (NMR) spectroscopy in solution went through several breakthroughs, while maturing into a standard method of structural biology. With the introduction of TROSY (transverse relaxation-optimized spectroscopy), the range of accessible molecular sizes was extended about thirty-fold, and efficient protein structure determination resulted from the demands of the structural genomics initiative. Applications in fundamental biology and biomedicine include studies of prion proteins and prion diseases (TSEs), the SARS-Corona virus proteome, trans-membrane signalling by G protein-coupled receptors (GPCRs), and signal transfer by pheromones.Key publications from the Kurt Wüthrich laboratories are placed in perspective, providing insights into new aspects of NMR spectroscopy in structural biology. In addition to methods development, this includes applications in diverse areas of biological research, such as prion proteins and their role in transmissible spongiform encephalopathies (TSEs), trans-membrane signal transfer by G protein-coupled receptors (GPCRs), structural characterization of the SARS-Corona virus proteome, metabolic-flux profiling in bacterial cultures, and signal transfers by pheromones.

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NMR in Structural Biology

NMR in Structural Biology

File Size : 3,3 MB
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The volume presents a survey of the research by Kurt Wthrich and his associates during the period 1965 to 1994. A selection of reprints of original papers on

NMR of Biological Macromolecules

NMR of Biological Macromolecules

File Size : 82,82 MB
Total View : 3328 Views
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Provided here are the latest techniques of NMR as applied to the study of proteins, carbohydrates and nucleic acids. The first chapters are devoted to an introd