Treatment with 2-Hydroxypropyl-β-Cyclodextrin Induces Macrophage Cholesterol Efflux in Vitro But Does Not Promote Lesion Regression in APOE Knockout Mice in Vivo

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  • Treatment with 2-Hydroxypropyl-β-Cyclodextrin Induces Macrophage Cholesterol Efflux in Vitro But Does Not Promote Lesion Regression in APOE Knockout Mice in Vivo Book Detail

  • Author : Menno Hoekstra
  • Release Date : 2017
  • Publisher :
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  • Pages :
  • ISBN 13 :
  • File Size : 55,55 MB
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Treatment with 2-Hydroxypropyl-β-Cyclodextrin Induces Macrophage Cholesterol Efflux in Vitro But Does Not Promote Lesion Regression in APOE Knockout Mice in Vivo by Menno Hoekstra PDF Summary

Book Description: BackgroundMacrophage cholesterol efflux is considered a therapeutic target to reduce atherosclerosis susceptibility and induce atherosclerotic lesion regression. 2-hydroxypropyl-u03b2-cyclodextrin (CD) has been suggested to remove cholesterol from cells. In this study, we investigated the effect of CD treatment on macrophage cholesterol efflux in vitro and the ability of established lesions to regress in response to lipid lowering.M&MPeritoneal macrophages were loaded with [3H]cholesterol or oxLDL to respectively study cholesterol efflux and foam cell formation in vitro. Western-type diet-fed APOE knockout mice were used to study lesion regression. ResultsCD treatment dose-dependently stimulated cholesterol efflux with the highest concentration of 20 mM CD inducing 41u00b12% of cholesterol efflux (P

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