Trends in Neuroimmunology: cross-talk between brain-resident and peripheral immune cells in both health and disease

Released on by Estela Maris Muñoz
preview-18

  • Trends in Neuroimmunology: cross-talk between brain-resident and peripheral immune cells in both health and disease Book Detail

  • Author : Estela Maris Muñoz
  • Release Date : 2024-06-26
  • Publisher : Frontiers Media SA
  • Genre : Medical
  • Pages : 177
  • ISBN 13 : 2832550827
  • File Size : 18,18 MB
DOWNLOAD BOOK

Trends in Neuroimmunology: cross-talk between brain-resident and peripheral immune cells in both health and disease by Estela Maris Muñoz PDF Summary

Book Description: The functional anatomy of organisms is maintained by the coordination of different systems, that often rely on particular interactions between specialized cells and between macromolecules. The immune system works with the circulatory and the lymphatic systems to protect most of the organs. However, some organs are considered immune privileged due to the presence of highly selective and regulated barriers, such as the blood-brain barrier (BBB) within the brain. The BBB controls periphery-brain molecule exchange and prevents immune effector cells from entering the homeostatic brain. BBB-associated elements, such as endothelial cells, pericytes, astrocytes, and microglia, potentially can function as antigen-presenting cells (APC). Pathological scenarios that induce dysfunction of the BBB and its associated cells may lead to the infiltration of lymphocytes crossing over from the blood to brain. Similarly, traumas can also enable B and T lymphocytes to pass bidirectionally between the CNS and the periphery, via the meningeal lymphatic vessels which drain into the cervical lymph nodes. Research in animals and in humans has revealed that B and T cells are involved in the progression of neurological diseases. It has been showed that under particular conditions, T cells establish themselves and become resident in the brain (T RM cells), from where they can either exert beneficial or detrimental effects on brain function. Amazing efforts have been made to further comprehend interactions between brain-specific cells and peripheral immune cells, and especially their roles and impact on the onset, progression, and eventual resolution of diverse brain pathologies.

Disclaimer: www.yourbookbest.com does not own Trends in Neuroimmunology: cross-talk between brain-resident and peripheral immune cells in both health and disease books pdf, neither created or scanned. We just provide the link that is already available on the internet, public domain and in Google Drive. If any way it violates the law or has any issues, then kindly mail us via contact us page to request the removal of the link.

Trends in Neuroimmunology

Trends in Neuroimmunology

File Size : 39,39 MB
Total View : 4141 Views
DOWNLOAD

Immunology has developed quite impressively over the past decade and perhaps very few fields in medicine or biology have grown so explosively. Completely new fi