Tumour microenvironment in cancer research and drug discovery

Released on by Syed Mahmood
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  • Tumour microenvironment in cancer research and drug discovery Book Detail

  • Author : Syed Mahmood
  • Release Date : 2024-05-10
  • Publisher : Frontiers Media SA
  • Genre : Science
  • Pages : 173
  • ISBN 13 : 2832548857
  • File Size : 5,5 MB
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Tumour microenvironment in cancer research and drug discovery by Syed Mahmood PDF Summary

Book Description: The implication of tumour microenvironment (TME) on cancer progression and therapeutic response has profoundly shifted the paradigms of molecular cancer research and drug discovery. The intricate networks of immune-inflammatory cells and signalling, cancer-associated fibroblasts, endothelial cells and adipose cells are extensively researched for diagnostics, therapeutics and predictive values. This includes siRNA and miRNA nanotherapeutics targeting these molecular components, owing to their powerful gene-silencing properties. Despite the concerted effort in the development of drug targeting TME, such as BLZ945 (a colony-stimulating factor-1 receptor inhibitor), there is a void in clinically satisfactory drug to target this intricate factor, thus far.

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