“What is Damage suppressor Protein?-A Tardigrade (water bear)-Unique DNA-associated Protein improves Radiotolerance in Human-cultured cells.’’

Released on by Dr.Hakim Saboowala
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  • “What is Damage suppressor Protein?-A Tardigrade (water bear)-Unique DNA-associated Protein improves Radiotolerance in Human-cultured cells.’’ Book Detail

  • Author : Dr.Hakim Saboowala
  • Release Date : 2020-02-02
  • Publisher : Dr.Hakim Saboowala
  • Genre : Medical
  • Pages : 45
  • ISBN 13 :
  • File Size : 47,47 MB
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“What is Damage suppressor Protein?-A Tardigrade (water bear)-Unique DNA-associated Protein improves Radiotolerance in Human-cultured cells.’’ by Dr.Hakim Saboowala PDF Summary

Book Description: Genomic DNA (Genomic deoxyribonucleic acid is chromosomal DNA, in contrast to extra-chromosomal DNAs like plasmids, abbreviated as gDNA) stores all genetic information and is indispensable for maintenance of normal cellular activity and propagation. Radiation causes severe DNA lesions, including double-strand breaks, and leads to genome instability and even lethality. Regardless of the toxicity of radiation, some organisms exhibit extraordinary tolerance against radiation. · These organisms are supposed to possess special mechanisms to mitigate radiation-induced DNA damages. Extensive study using radio-tolerant bacteria suggested that effective protection of proteins and enhanced DNA repair system play important roles in tolerability against high-dose radiation. Recent studies using an extremotolerant animal, the tardigrade, provides new evidence that a tardigrade-unique DNA-associating protein, termed Dsup, suppresses the occurrence of DNA breaks by radiation in human-cultured cells. An attempt has been made in this Booklet to provide a brief summary of the current knowledge on extremely radiotolerant animals, and present novel insights from the tardigrade research, which expand our understanding on molecular mechanism of exceptional radio-tolerability. ……. Dr. H. K. Saboowala.M.B.(BoM) M.R.S.H.(London)

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